HORDB

ID: hor005226
Uniprot ID: P0C234
Protein name: Calcitonin
Gene name: NA
Organism: Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
Family: Calcitonin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Lithobates (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P0C234-F1.pdb

hor005226_AF2.pdb

hor005226_ESM.pdb

Mass:	397902	Formula:	C145H234N44O46S3
Absent amino acids:	EIW	Common amino acids:	LS
pI:	8.8	Basic residues:	4
Polar residues:	15	Hydrophobic residues:	8
Hydrophobicity:	-26.25	Boman Index:	-5099
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	64.06
Instability Index:	763.44	Extinction Coefficient cystines:	1615
Absorbance 280nm:	52.1